(4aS,7aS)-tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate → (4aS,7aS)-tert-Butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

HRID 2256083

Reaktionsgleichung

Reaktionsgleichung von HRID 2256083
C([N:8]1[CH2:16][C@H:15]2[C@H:10]([N:11]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:12][CH2:13][CH2:14]2)[CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[C:20]([O:19][C:17]([N:11]1[CH2:12][CH2:13][CH2:14][C@H:15]2[CH2:16][NH:8][CH2:9][C@@H:10]12)=[O:18])([CH3:23])([CH3:21])[CH3:22]

Komponenten

4

Edukt 1

HCID 29973012(4aS,7aS)-tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

Produkt 1

HCID 1519435(4aS,7aS)-tert-Butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylateAusbeute 99,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

In 130 ml of ethanol was dissolved 3.86 g of (4aS,7aS) -6-benzyl-1-t-butoxycarbonyloctahydropyrrolo[3.4-b]pyridine, and 1 g of 5% palladium-on-carbon was added thereto. While the reaction vessel was heated by a tungsten lamp, hydrogenation was conducted under pressurized hydrogen gas atmosphere of 4 kg/cm2 for 4 hours. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was concentrated to give 2.75 g of the titled compound.

Aufarbeitung

  1. additionwas added
  2. temperatureWhile the reaction vessel was heated by a tungsten lamp
  3. customAfter completion of the reaction
  4. customthe catalyst was removed by filtration
  5. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-e17d5fd2f7eb4fd6b97865188dfcc53f
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05654318

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