Ammonia → 6-Amino-2-fluoronicotinamide

HRID 2256174Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2256174
[F:1][C:2]1[N:10]=[C:9](F)[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[NH3:12].O>C(N)=O>[NH2:12][C:9]1[CH:8]=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([F:1])[N:10]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 962WaterHCID 105830482,6-Difluoropyridine-3-carboxamide

Produkt 1

HCID 105348946-Amino-2-fluoronicotinamideAusbeute 31 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 713FormamideLösungsmittel

Versuchsvorschrift

A solution of 2,6-difluoronicotinamide (4.68 g, 0.029 mmol) in dry formamide (30 mL) is saturated with ammonia and allowed to stand at room temperature for 24 h. Water (50 mL) is added and the resultant precipitate is filtered off and washed well with water, to give 6-amino-2-fluoronicotinamide (1.41 g, 31%) mp 236°-237° C. 1H NMR (DMSO) δ 7.89 (1H, dd, J=10.4, 8.4 Hz), 7.31, 7.16 (1H, 1H, 2 brs,), 6.93 (2H, brs), 6.36 (1H, dd, J=8.4, 2.4 Hz).

Aufarbeitung

  1. filtrationthe resultant precipitate is filtered off
  2. washwashed well with water

Quellen und Nachweise

ORD-Eintrag
ord-ea483090fd004c038894c25409b88815
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05654307

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