Dimethylformamide → 2-(2-Propen-1-ylthio)pyrazine

0.58 g of allyl alcohol was dissolved in 50 ml of dichloromethan and 2.89 g of triphenylphosphine and 1.96 g of N-bromosuccinimide were added thereto. The mixture was stirred at room temperature for 30 minutes, and 5 ml of dimethylformamide solution in which 1.0 g of 2-mercaptopyrazine and 1 ml of triethylamine were dissolved was added to the above solution. The resulting mixture was stirred at room temperature for 1 hour and poured into 100 ml of water. The organic layer was separated and concentrated to dryness. The residues were purified by silica gel chromatography using ethyl acetate:n-hexane=1:1 as an eluate to give 0.6 g of titled compound.

1. additionwas added to the above solution
2. stirringThe resulting mixture was stirred at room temperature for 1 hour
3. customThe organic layer was separated
4. concentrationconcentrated to dryness
5. customThe residues were purified by silica gel chromatography

ORD-Eintrag

ord-567a66f0b28244a88f5fb2b6b1881f56

Quelldatensatz

uspto-grants-1997_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05658913