1,4,7,10-Tetraazacyclododecane → alpha-Ethyl-2,4,6-triiodo-3-[[1-oxo-6-[(1,4,7,10-tetraazacyclododec-1-yl-acetyl)amino]hexyl]amino]benzenepropanoic acid

HRID 2258398

Reaktionsgleichung

Reaktionsgleichung von HRID 2258398
[NH:1]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][NH:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[CH2:14][C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([NH:25][C:26]1[C:27]([I:41])=[C:28]([CH2:34][CH:35]([CH2:39][CH3:40])[C:36]([OH:38])=[O:37])[C:29]([I:33])=[CH:30][C:31]=1[I:32])=[O:24])=[O:16]>CC(N(C)C)=O>[CH2:39]([CH:35]([CH2:34][C:28]1[C:29]([I:33])=[CH:30][C:31]([I:32])=[C:26]([NH:25][C:23](=[O:24])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][NH:17][C:15](=[O:16])[CH2:14][N:1]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][NH:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[C:27]=1[I:41])[C:36]([OH:38])=[O:37])[CH3:40]

Komponenten

4

Edukt 2

HCID 649631,4,7,10-TetraazacyclododecaneHCID 229214013-[[6-[(Chloroacetyl)amino]-1-oxohexyl]amino]-alpha-ethyl-2,4,6-triiodobenzenepropanoic acid

Produkt 1

HCID 22921393alpha-Ethyl-2,4,6-triiodo-3-[[1-oxo-6-[(1,4,7,10-tetraazacyclododec-1-yl-acetyl)amino]hexyl]amino]benzenepropanoic acidAusbeute 59 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel2×

Versuchsvorschrift

According to the procedure described in Example 5, 171.3 g of 1,4,7,10-tetraazacyclododecane (1,00 mol) in 500 ml of DMA are reacted with 190 g of 3-[[6-[(chloroacetyl) amino]-1-oxohexyl]amino]-α-ethyl-2,4,6-triiodobenzenepropanoic acid (prepared according to the procedure described in Example 2) (0,25 mol) in 250 ml of DMA. 155 g of α-ethyl-2,4,6-triiodo-3-[[1-oxo-6-[(1,4,7,10-tetraazacyclododec-1-yl-acetyl)amino]hexyl]amino]benzenepropanoic acid (0.147 mol) are obtained.

Aufarbeitung

  1. customprepared

Quellen und Nachweise

ORD-Eintrag
ord-d3a29fcf993e497388fdefede7c9e7bc
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05660814

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