1,8-Naphthyridine → 1,2,3,4-Tetrahydro-1,8-naphthyridine

HRID 225846

Reaktionsgleichung

Reaktionsgleichung von HRID 225846
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][N:9]=2)[CH:4]=[CH:3][CH:2]=1>C(O)C.[Pd]>[NH:9]1[C:10]2[C:5](=[CH:4][CH:3]=[CH:2][N:1]=2)[CH2:6][CH2:7][CH2:8]1

Komponenten

4

Edukt 1

HCID 1360691,8-Naphthyridine

Produkt 1

HCID 130473671,2,3,4-Tetrahydro-1,8-naphthyridineAusbeute 100,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

1,8-Naphthyridine (1.0 g, 7.68 mmole) was hydrogenated (50 psi) with 10% Pd/C (100 mg) in absolute ethanol (40 mL) for 18 hr. The mixture was filtered through a pad of Celite® and the filtrate was concentrated to give the title compound (1.04 g) which was sufficiently pure for use in the next step: MS (ES) m/e 135 (M+H)+.

Aufarbeitung

  1. customfor 18 hr
  2. filtrationThe mixture was filtered through a pad of Celite®
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-82a58752556d48e6a1823e5f14201893
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07557125B2

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