Hydrochloric Acid → HCID 22922296, Verbindung
Reaktionsgleichung
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)([CH2:14][S:15]([CH2:18][C:19]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=2)(=[O:17])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:39]>C(OCC)C>[ClH:39].[C:33]1([C:11]2([CH2:14][S:15]([CH2:18][C:19]3[CH:20]=[C:21]([C:29]([F:30])([F:31])[F:32])[CH:22]=[C:23]([C:25]([F:27])([F:28])[F:26])[CH:24]=3)(=[O:16])=[O:17])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
1t-Butoxycarbonyl-4-phenyl-4-[3,5-bis(trifluoromethyl) benzylsulphonyl methyl]piperidine was dissolved in diethyl ether (5 ml) and ethereal HCl (5 ml) was added. The solution was left standing for 16 h, solvent was removed and residue was recrystallised from isopropyl alcohol/isopropyl ether giving 4-phenyl-4-[3,5-bis(trifluoromethyl)benzylsulphonylmethyl]piperidine hydrochloride (196 mg) as a white solid, m.p. 249° C. (dec), m/z (CI+) 466 (M+ +1). Found: C, 49.90; H, 4.36; N, 2.89. C21H21NO2SF6. HCl requires C, 50.25; H, 4.42; N, 2.79.