ethyl 1-methyl-1H-indole-2-carboxylate → N,1-Dimethyl-5-fluoro-1H-indole-2-carboxamide

HRID 225867

Reaktionsgleichung

Reaktionsgleichung von HRID 225867
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([C:12]([O:14]CC)=O)=[CH:5]2.[CH3:17][N:18]1C2C(=CC=CC=2)C=C1C(OCC)=O>>[CH3:17][NH:18][C:12]([C:6]1[N:7]([CH3:11])[C:8]2[C:4]([CH:5]=1)=[CH:3][C:2]([F:1])=[CH:10][CH:9]=2)=[O:14]

Komponenten

3

Edukt 2

HCID 143368ethyl 1-methyl-1H-indole-2-carboxylateHCID 10775338Ethyl 5-fluoro-1-methyl-1H-indole-2-carboxylate

Produkt 1

HCID 22593743N,1-Dimethyl-5-fluoro-1H-indole-2-carboxamideAusbeute 68 %

Versuchsvorschrift

According to the procedure of Preparation 1(b), except substituting ethyl 5-fluoro-1-methyl-1H-indole-2-carboxylate for the ethyl 1-methyl-1H-indole-2-carboxylate, the title compound (2.1 g, 68%) was prepared as a white solid: MS (ES) m/e 207 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-5937838202174a5190a842483394e586
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07557125B2

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