1-Chloro-2-nitrobenzene → 1-Fluoro-2-nitrobenzene

HRID 2260454

Reaktionsgleichung

Reaktionsgleichung von HRID 2260454
[F-:1].[K+].[Cl-].[NH4+].CC(CC(O)CO)C.Cl[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N+:20]([O-:22])=[O:21].C1(C)C(C)=CC=CC=1>[Cl-].C[N+](C)(C)C>[F:1][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N+:20]([O-:22])=[O:21]

Komponenten

7

Edukt 5

HCID 69451-Chloro-2-nitrobenzeneHCID 7237O-XyleneHCID 25517Ammonium ChlorideHCID 911714-Methylpentane-1,2-diolHCID 522689Potassium Fluoride

Produkt 1

HCID 738951-Fluoro-2-nitrobenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6379Tetramethylammonium chlorideKatalysator

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

In a 2-liter flange flask fitted with a distillation bridge and impeller stirrer, 290.5 g (5.0 mol) of potassium fluoride, 71.1 g (0.1 mol) of trimethyl (ethoxypolyoxypropyl) ammonium chloride, 11.0 g (0.1 mol) of tetramethylammonium chloride and 17.7 g (0.035 mol) of polyethylene glycol dimethyl ether 500 were introduced at 120° C. into the melt of 630 g (4.0 mol) of 2-chloronitrobenzene. Subsequently, 100 g (0.38 mol) of xylene were added and the reaction mixture was stirred for 21 hours at a temperature of 150° C. Amount of 2-fluoronitrobenzene formed, according to GC analysis:

Quellen und Nachweise

ORD-Eintrag
ord-465347a2c41342d48226a5bbf0083f9d
Quelldatensatz
uspto-grants-1995_12
Patentnummer
US05476976

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