Sodium Carbonate → 1-(2'-Hexyldecyl)-2-ethyl-4,5,6,7-tetrahydrobenzimidazole

HRID 2260470Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2260470
[CH2:1]([C:3]1[NH:4][C:5]2[CH2:11][CH2:10][CH2:9][CH2:8][C:6]=2[N:7]=1)[CH3:2].Br[CH2:13][CH:14]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].C(=O)([O-])[O-].[Na+].[Na+]>COCCO>[CH2:23]([CH:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH2:13][N:7]1[C:6]2[CH2:8][CH2:9][CH2:10][CH2:11][C:5]=2[N:4]=[C:3]1[CH2:1][CH3:2])[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 18459580Pentadecane, 7-(bromomethyl)-HCID 189979322-Ethyl-4,5,6,7-tetrahydrobenzimidazole

Produkt 1

HCID 189979291-(2'-Hexyldecyl)-2-ethyl-4,5,6,7-tetrahydrobenzimidazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80192-MethoxyethanolLösungsmittel

Versuchsvorschrift

2-Ethyl-4,5,6,7-tetrahydrobenzimidazole (14.3 parts), 2-methoxyethanol (30 parts), 1-bromo-2-hexyldecane (35 parts) and sodium carbonate (5.7 parts) are stirred together and heated at 125°-135° C. below a reflux condenser for 15 hours. The reaction mixture is cooled and extracted with a mixture of toluene (150 parts) and ethyl acetate (50 parts) and the extract is washed successively with water, dilute sulphuric acid, dilute sodium hydroxide, and water, and then distilled yielding 1-(2'-hexyldecyl)-2-ethyl-4,5,6,7-tetrahydrobenzimidazole (V) (16.6 parts), b.p. 185°-200° at 0.2 mm pressure.

Aufarbeitung

  1. temperatureheated at 125°-135° C. below a reflux condenser for 15 hours
  2. temperatureThe reaction mixture is cooled
  3. extractionextracted with a mixture of toluene (150 parts) and ethyl acetate (50 parts)
  4. washthe extract is washed successively with water, dilute sulphuric acid, dilute sodium hydroxide, and water
  5. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-545b4c0de776409085a77ad9539a0544
Quelldatensatz
uspto-grants-1995_12
Patentnummer
US05478539

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