Acetic Acid → HCID 11276149, Verbindung
Reaktionsgleichung
C[O:2][C:3](=O)[CH2:4][CH2:5][C:6]1[C:7](=[O:15])[N:8]([CH2:12][CH:13]=[CH2:14])[CH2:9][CH2:10][CH:11]=1.CO.[NH2:19][O:20][K].C(O)(=O)C>C(OCC)(=O)C>[CH2:12]([N:8]1[CH2:9][CH2:10][CH:11]=[C:6]([CH2:5][CH2:4][C:3]([NH:19][OH:20])=[O:2])[C:7]1=[O:15])[CH:13]=[CH2:14]Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
24 mg of 3-(1-allyl-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl)-propionic acid methyl ester (i1) prepared from the above Step 2 was dissolved in methanol solution (0.11 mmol) and then 0.122 ml of 1.7M NH2OK suspension solution (0.207 mmol) was added thereto at 0° C. and stirred for 3 hrs at room temperature. The resulting mixture was neutralized with 0.02 ml of acetic acid, diluted with 10 ml of ethyl acetate solution, filtered and concentrated in vacuo. The resulting compound was purified by column chromatography on Silica gel with methanol/chloroform (1:10) solvent mixture as an eluant to give 11 mg (yield: 48%) of the title compound (j1).
Aufarbeitung
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe resulting compound was purified by column chromatography on Silica gel with methanol/chloroform (1:10) solvent mixture as an eluant
Quellen und Nachweise
- ORD-Eintrag
- ord-6d4951398b7b44acba254a510295924f
- Quelldatensatz
- uspto-grants-2010_12
- Patentnummer
- US07846963B2
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