Nitric Acid → 3-Nitro-7-azaindole
Reaktionsgleichung
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.[N+:10]([O-])([OH:12])=[O:11].C(=O)(O)[O-].[Na+]>O>[N+:10]([C:3]1[C:4]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:1][CH:2]=1)([O-:12])=[O:11]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
3-nitro-7-azaindole 504 is prepared by adding 7-azaindole 1 to fuming nitric acid while cooling (e.g. 0° C.). After stirring for one to several hours, water is carefully added and the mixture neutralized with saturated sodium bicarbonate. The solids are collected by filtration and dried to provide 3-nitro-7-azaindole 504.
Aufarbeitung
- custom3-nitro-7-azaindole 504 is prepared
- additionis carefully added
- filtrationThe solids are collected by filtration
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-1027350a444c46258b8064a316302465
- Quelldatensatz
- uspto-grants-2010_12
- Patentnummer
- US07846941B2
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