Methanol → 2-(3-(Methylsulfonyl)propyl)isoindoline-1,3-dione

HRID 2262263Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2262263
CS[CH2:3][CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16].O[O:18][S:19]([O-:21])=O.[K+].[CH3:23]O>O>[CH3:23][S:19]([CH2:3][CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16])(=[O:21])=[O:18]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 134589972-[3-(Methylsulfanyl)propyl]-1H-isoindole-1,3(2H)-dioneHCID 23707502Potassium hydroxy sulfite

Produkt 1

HCID 134590592-(3-(Methylsulfonyl)propyl)isoindoline-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a solution of 2-(3-methylsulfanyl-propyl)-isoindole-1,3-dione (440 mg) in methanol (10 mL) was added a solution of oxone (1.73 g) in water (10 mL) and the reaction stirred at room temperature for 16 h. The reaction was then diluted with water (20 mL) and extracted into dichloromethane (2×20 mL). The combined organics were washed with aqueous brine solution (2×20 mL), dried (MgSO4) and reduced in vacuo to give 2-(3-methanesulfonyl-propyl)-isoindole-1,3-dione as a white solid.

Aufarbeitung

  1. extractionextracted into dichloromethane (2×20 mL)
  2. washThe combined organics were washed with aqueous brine solution (2×20 mL)
  3. dry with materialdried (MgSO4)

Quellen und Nachweise

ORD-Eintrag
ord-ec63c011e2fb47069916147c21f7e919
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07846929B2

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