Ethyl bromoacetate → (2-Acetyl-4-methoxy-phenoxy)-acetic acid ethyl ester

HRID 226263

Reaktionsgleichung

Reaktionsgleichung von HRID 226263
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[OH:12])=[O:3].C(=O)([O-])[O-].[K+].[K+].Br[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>CCC(C)=O>[CH2:24]([O:23][C:21](=[O:22])[CH2:20][O:12][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH3:11])=[CH:9][C:4]=1[C:2](=[O:3])[CH3:1])[CH3:25]

Komponenten

5

Edukt 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 697141-(2-Hydroxy-5-methoxyphenyl)ethan-1-one

Produkt 1

HCID 15643798(2-Acetyl-4-methoxy-phenoxy)-acetic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Versuchsvorschrift

A mixture of 16.6 g (100.0 mmol) of 2-hydroxi-5-methoxyacetophenone, 20 g (208 mmol) of potassium carbonate, 16.7 g (100.0 mmol) of ethyl bromoacetate and 200 ml of MEK is stirred at reflux temperature for 10 hr. The solids are filtered and the filtrate concentrated. The residue is suspended in water and the solid is filtered and dried. Yield: 10.2 g (40%).

Aufarbeitung

  1. temperatureat reflux temperature for 10 hr
  2. filtrationThe solids are filtered
  3. concentrationthe filtrate concentrated
  4. filtrationthe solid is filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-60bd36e5ee7d4e22abc36d0cbb75c24c
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07557212B2

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