4-Fluoro-3-nitrobenzoic acid → 3-Nitro-4-(3-thiazol-2-yl-phenylamino)benzoic acid

HRID 2262732Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2262732
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:7]=[C:8]([NH2:12])[CH:9]=[CH:10][CH:11]=1.F[C:14]1[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][C:15]=1[N+:23]([O-:25])=[O:24]>CN1C(=O)CCC1.O>[N+:23]([C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:14]=1[NH:12][C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([C:2]2[S:1][CH:5]=[CH:4][N:3]=2)[CH:7]=1)[C:18]([OH:20])=[O:19])([O-:25])=[O:24]

Komponenten

5

Edukt 2

HCID 679874-Fluoro-3-nitrobenzoic acidHCID 110193903-(1,3-Thiazol-2-yl)aniline

Produkt 1

HCID 575722503-Nitro-4-(3-thiazol-2-yl-phenylamino)benzoic acidAusbeute 83,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Versuchsvorschrift

To a solution of 3-thiazol-2-yl-phenylamine (14.0 g, 79 mmol) in anhydrous NMP (50 ml) was added 4-fluoro-3-nitrobenzoic acid (15.0 g, 127 mmol). The resultant mixture was stirred at 90° C. over night. The cooled reaction cake was suspended in water and the solid was filtered off, washed with water and dried in the air to afford the desired product (22.5 g, 83%).

Aufarbeitung

  1. customThe cooled reaction cake
  2. filtrationthe solid was filtered off
  3. washwashed with water
  4. customdried in the air

Quellen und Nachweise

ORD-Eintrag
ord-6e4db7c9b4af47d48f91526c47b2ec4b
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07851490B2

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