Methanol → Pyrrolidinone, (4-aminophenyl)-

HRID 2263231

Reaktionsgleichung

Reaktionsgleichung von HRID 2263231
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])=[CH:6][CH:5]=1)([O-])=O.CO>[Pd].O1CCCC1>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])=[CH:6][CH:5]=1

Komponenten

5

Edukt 2

HCID 887MethanolHCID 2993281-(4-Nitrophenyl)pyrrolidin-2-one

Produkt 1

HCID 676146Pyrrolidinone, (4-aminophenyl)-Ausbeute 92,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 1-(4-nitrophenyl)pyrrolidin-2-one (1.00 g, 4.85 mmol), 10% palladium on carbon (100 mg), methanol (20 ml) and tetrahydrofuran (20 ml) was stirred under hydrogen atmosphere for 12 hours, insoluble substances were removed by filtration, and the filtrate was concentrated to give 790 mg (92.5%) of the desired product as an oil.

Aufarbeitung

  1. custominsoluble substances were removed by filtration
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-e710ceef379b475083c097f649ae98ea
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07851473B2

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