Ethanolamine → HCID 10273208, Verbindung

HRID 2264519Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2264519
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:18]=[CH:17][C:13]3[O:14][CH2:15][O:16][C:12]=3[CH:11]=2)[C:5]([C:19]#[N:20])=[C:4]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:3]=1.[OH:29][CH2:30][CH2:31][NH2:32].O>C1COCC1>[OH:29][CH2:30][CH2:31][NH:32][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:18]=[CH:17][C:13]3[O:14][CH2:15][O:16][C:12]=3[CH:11]=2)[C:5]([C:19]#[N:20])=[C:4]([O:21][CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:3]=1

Komponenten

5

Edukt 3

HCID 700EthanolamineHCID 962WaterHCID 17976006HCID 17976006, Verbindung

Produkt 1

HCID 10273208HCID 10273208, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

30 mg (0.08 mmol) of 2-chloro-4-(1,3-benzodioxol-5-yl)-6-benzyloxy-3,5-pyridinedicarbonitrile (example 4, step 1) and 14.1 mg (0.23 mmol) of 2-hydroxyethylamine are shaken together in 0.5 ml of THF for about 16 h. Water is added to the reaction solution and the product that crystallizes out is filtered off with suction and dried under reduced pressure. The crude product is purified by silica gel chromatography using the mobile phases dichloromethane and dichloromethane/methanol 50:1.

Aufarbeitung

  1. customthe product that crystallizes out
  2. filtrationis filtered off with suction
  3. customdried under reduced pressure
  4. customThe crude product is purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-9fc9f445ad414b4d83b4713a43bd5124
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07855219B2

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