Tert-butyl {2-[3-(benzyloxy)phenyl]ethyl}carbamate → tert-Butyl 3-hydroxyphenethylcarbamate

HRID 2264660Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2264660
[C:1]([O:5][C:6](=[O:24])[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16]CC2C=CC=CC=2)[CH:11]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:24])[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 1

HCID 59596820Tert-butyl {2-[3-(benzyloxy)phenyl]ethyl}carbamate

Produkt 1

HCID 11031911tert-Butyl 3-hydroxyphenethylcarbamateAusbeute 101,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

1 g of Pd/C 10% was added to a solution of 13 g (0.039 mol) of [2-(3-benzyloxy-phenyl)ethyl]-carbamic acid tert-butyl ester in 100 ml of ethanol. The mixture was hydrogenated at 40 psi overnight. The catalyst was filtered off and washed with ethanol. The solvent was removed under vacuum and 9.4 g of the title compound were obtained as a colourless oil in quantitative yield.

Aufarbeitung

  1. customwas hydrogenated at 40 psi overnight
  2. filtrationThe catalyst was filtered off
  3. washwashed with ethanol
  4. customThe solvent was removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-cb56cc3514db4963bb776467a6312afc
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07855227B2

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