Methanesulfonic Acid → 8-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one

HRID 2266501Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2266501
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[NH:9][C:10](=[O:26])[CH:11]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([CH3:25])(=[O:24])=[O:23])=[CH:18][CH:17]=1)[C:12](=O)[CH3:13].CS(O)(=O)=O>C([O-])(=O)C.[Na+]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]2[C:3]=1[NH:9][C:10](=[O:26])[C:11]([CH2:15][C:16]1[CH:17]=[CH:18][C:19]([S:22]([CH3:25])(=[O:24])=[O:23])=[CH:20][CH:21]=1)=[C:12]2[CH3:13]

Komponenten

4

Edukt 2

HCID 6395Methanesulfonic AcidHCID 86631439N-(2-chloro-5-hydroxyphenyl)-2-(4-methanesulfonylbenzyl)-3-oxo-butyramide

Produkt 1

HCID 687847618-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 517045Sodium AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of N-(2-chloro-5-hydroxyphenyl)-2-(4-methanesulfonylbenzyl)-3-oxo-butyramide (0.25 g) and methanesulfonic acid (1.1 g) was heated at 100° C. for 10 minutes. The mixture cooled to room temperature and poured into a saturated aqueous solution of sodium acetate (20 mL). The resulting precipitate was collected by filtration, washed with water and dried to afford title compound as a pale pink solid, 0.21 g.

Aufarbeitung

  1. temperatureThe mixture cooled to room temperature
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c3b35f5ecd144c3199fae07c69245444
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07858640B2

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