(S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl ester → (S)-2-[3-(2-chloro-4-cyclobutylcarbamoylbenzyl)-2-ethyl-8-fluoro-4-oxo-1,4-dihydroquinolin-5-yloxy]propionic Acid Methyl Ester

HRID 2266630

Reaktionsgleichung

Reaktionsgleichung von HRID 2266630
C([O:3][C:4](=O)[CH:5]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17](=[O:23])[NH:18][CH:19]2[CH2:22][CH2:21][CH2:20]2)=[CH:13][C:12]=1[Cl:24])[C:6](=O)[CH2:7][CH3:8])C.[CH3:26][O:27][C:28](=[O:40])[C@@H:29]([O:31][C:32]1[CH:37]=[CH:36][C:35]([F:38])=[C:34]([NH2:39])[CH:33]=1)[CH3:30]>>[CH3:26][O:27][C:28](=[O:40])[C@@H:29]([O:31][C:32]1[CH:37]=[CH:36][C:35]([F:38])=[C:34]2[C:33]=1[C:4](=[O:3])[C:5]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17](=[O:23])[NH:18][CH:19]3[CH2:22][CH2:21][CH2:20]3)=[CH:13][C:12]=1[Cl:24])=[C:6]([CH2:7][CH3:8])[NH:39]2)[CH3:30]

Komponenten

3

Edukt 2

HCID 66717596(S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl esterHCID 687826112-(2-chloro-4-cyclobutylcarbamoylbenzyl)-3-oxopentanoic Acid Ethyl Ester

Produkt 1

HCID 68784731(S)-2-[3-(2-chloro-4-cyclobutylcarbamoylbenzyl)-2-ethyl-8-fluoro-4-oxo-1,4-dihydroquinolin-5-yloxy]propionic Acid Methyl Ester

Versuchsvorschrift

The title compound was prepared by the method of Preparation 65c using 2-(2-chloro-4-cyclobutylcarbamoylbenzyl)-3-oxopentanoic acid ethyl ester and (S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl ester.

Quellen und Nachweise

ORD-Eintrag
ord-28a08cdc21da43d8a37c48fe4c875e78
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07858640B2

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