1,4-Benzodioxan-6-ylamine → N2-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(2-hydro xy-2-phenylethyl)-2,4-pyrimidinediamine

HRID 226700

Reaktionsgleichung

Reaktionsgleichung von HRID 226700
C1COC2C=CC([NH:11][C:12]3[C:17]([F:18])=[CH:16][N:15]=[C:14]([NH:19][C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([OH:26])[CH:21]=4)[N:13]=3)=CC=2O1.ClC1N=C(N[CH2:35][CH:36]([OH:43])[C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)C(F)=CN=1.[CH2:45]1[CH2:55]OC2C=CC(N)=CC=2[O:46]1>>[CH2:55]1[CH2:45][O:46][C:23]2[CH:24]=[CH:25][C:20]([N:19]([CH2:35][CH:36]([OH:43])[C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[C:14]3[N:13]=[C:12]([NH2:11])[C:17]([F:18])=[CH:16][N:15]=3)=[CH:21][C:22]=2[O:26]1

Komponenten

4

Edukt 3

HCID 891481,4-Benzodioxan-6-ylamineHCID 22060334N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-primidinediamineHCID 220608272-chloro-5-fluoro-N4-(2-hydroxy-2-phenylethyl)-4-pyrimidineamine

Produkt 1

HCID 22060669N2-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(2-hydro xy-2-phenylethyl)-2,4-pyrimidinediamine

Versuchsvorschrift

In a manner similar to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N4-(2-hydroxy-2-phenylethyl)-4-pyrimidineamine and 3,4-ethylenedioxyaniline were reacted to yield N2-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(2-hydroxy-2-phenylethyl)-2,4-pyrimidinediamine.

Aufarbeitung

  1. customwere reacted

Quellen und Nachweise

ORD-Eintrag
ord-0f20c43f67914c2ab846aa746d95d6eb
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07557210B2

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