4-dimethylamino-2-[2-(4-fluorophenyl)acetyl]-pyrazolidine-1-carboxylic acid benzyl ester HCl salt → 1-(4-Dimethylamino-pyrazolidin-1-yl)-2-(4-fluorophenyl)-ethanone
Reaktionsgleichung
Cl.C(OC([N:12]1[CH2:16][CH:15]([N:17]([CH3:19])[CH3:18])[CH2:14][N:13]1[C:20](=[O:29])[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)=O)C1C=CC=CC=1>CO.[Pd]>[CH3:19][N:17]([CH3:18])[CH:15]1[CH2:14][N:13]([C:20](=[O:29])[CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[NH:12][CH2:16]1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
4-dimethylamino-2-[2-(4-fluorophenyl)acetyl]-pyrazolidine-1-carboxylic acid benzyl ester HCl salt, 21, (4.22 g, 10 mmol) is dissolved in methanol and Pd/C (100 mg) is added. The solution is then hydrogenated of a Parr® Hydrogenation Apparatus 18 hours after which time the catalyst is removed by filtration and the filtrate concentrated in vacuo to afford the desired product.