Hydrochloric Acid → Piperidin-4-yl pivalate

HRID 2267705Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2267705
C([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15](=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17])[CH2:10][CH2:9]1)C1C=CC=CC=1.Cl>CO.[Pd]>[NH:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15](=[O:20])[C:16]([CH3:18])([CH3:17])[CH3:19])[CH2:10][CH2:9]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 668415652,2-Dimethyl-propionic acid 1-benzyl-piperidin-4-yl ester

Produkt 1

HCID 57464983Piperidin-4-yl pivalate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of piperidine 51 (35.99 g, 130.7 mmol) in methanol is hydrogenated with Pd/C in the presence of one equivalent of HCl (104.5 ml, 130.7 mmol, 1.25M in MeOH). After filtration and evaporation, the crude is taken up in ether and washed with 1N—NaOH and brine. Drying, evaporation and distillation (0.08 mbar, 75-90 C) gave a colourless oil. Yield: 17.98 g (74%).

Aufarbeitung

  1. filtrationAfter filtration and evaporation
  2. washwashed with 1N—NaOH and brine
  3. customDrying
  4. customevaporation and distillation (0.08 mbar, 75-90 C)
  5. customgave a colourless oil

Quellen und Nachweise

ORD-Eintrag
ord-6331622090a44f008539bbb5c8ccca71
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07858781B2

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