Trifluoroacetic acid → HCID 18614298, Verbindung

HRID 2268119Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2268119
C([O:8][C:9]1[CH:10]=[C:11]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[O:12][C:13]1[C:18]([CH3:19])=[CH:17][C:16]([N+:20]([O-:22])=[O:21])=[CH:15][C:14]=1[CH3:23])C1C=CC=CC=1.C(O)(C(F)(F)F)=O.C1(SC)C=CC=CC=1>>[OH:8][C:9]1[CH:10]=[C:11]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[O:12][C:13]1[C:14]([CH3:23])=[CH:15][C:16]([N+:20]([O-:22])=[O:21])=[CH:17][C:18]=1[CH3:19]

Komponenten

4

Edukt 3

HCID 6422Trifluoroacetic acidHCID 7520ThioanisoleHCID 18614245HCID 18614245, Verbindung

Produkt 1

HCID 18614298HCID 18614298, VerbindungAusbeute 95,4 %

Versuchsvorschrift

A solution of 4-(3-benzyloxy-4-methoxyphenoxy)-3,5-dimethylnitrobenzene (1.65 g), TFA (3.5 mL) and thioanisole (2.2 mL) were stirred for 4 h. The reaction was partitioned between ethyl acetate and water, the organic layer dried over sodium sulfate and concentrated in vacuo. Flash chromatography afforded 4-(3-hydroxy-4-methoxyphenoxy)-3,5-dimethylnitrobenzene (1.2 g) as a yellow oil.

Aufarbeitung

  1. customThe reaction was partitioned between ethyl acetate and water
  2. dry with materialthe organic layer dried over sodium sulfate
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e16fe9a1cf714d3880266ee602cd6636
Quelldatensatz
uspto-grants-2001_12
Patentnummer
US06326398B1

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