Phenol, 4-methoxy-2-nitro- → 2-Amino-4-methoxyphenol

HRID 22698

Reaktionsgleichung

Reaktionsgleichung von HRID 22698
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[C:5]([N+:10]([O-])=O)[CH:4]=1>CO.[Pd]>[NH2:10][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[OH:9]

Komponenten

4

Edukt 1

HCID 15285Phenol, 4-methoxy-2-nitro-

Produkt 1

HCID 14191082-Amino-4-methoxyphenol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 4-methoxy-2-nitrophenol 11 (10 g, 59.1 mmol) and Pd/C (1.0 g) in methanol (100 ml) was placed on a Parr shaker under H2 (50 psi) for 60 minutes. The reaction mixture was filtered through Celite 521 and the filter cake washed with MeOH. The filtrate was evaporated (in vacuo), to yield compound 12 as a tan solid.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite 521
  2. washthe filter cake washed with MeOH
  3. customThe filtrate was evaporated (in vacuo)

Quellen und Nachweise

ORD-Eintrag
ord-4d5d8283e50c4141aca07510c1511933
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849632B2

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