Diethyl (ethoxymethylene)malonate → Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate

HRID 226984

Reaktionsgleichung

Reaktionsgleichung von HRID 226984
[CH2:1]([O:3][C:4](=[O:15])[C:5](=[CH:11]OCC)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2].[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[N:18]=1>>[CH2:9]([O:8][C:6](=[O:7])[C:5](=[CH:11][NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[N:18]=1)[C:4]([O:3][CH2:1][CH3:2])=[O:15])[CH3:10]

Komponenten

3

Edukt 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 157652-Amino-6-methylpyridine

Produkt 1

HCID 83264Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonateAusbeute 84,7 %

Versuchsvorschrift

20 g (92.5 mmol) of 2-ethoxymethylene-malonic acid diethyl ester and 10 g (92.5 mmol) of 2-amino-6-methylpyridine were heated neat at 110° C. for 2 h. The reaction was allowed to cool to room temperature and the product was recrystallized from dichloromethane and hexane to afford 21.8 g of 2-[(6-Methyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester as a white solid.

Aufarbeitung

  1. customthe product was recrystallized from dichloromethane and hexane

Quellen und Nachweise

ORD-Eintrag
ord-6679bb50a1b64b42a9bc552543a97405
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07557213B2

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