Hydrochloric Acid → 193813-77-3

HRID 2270054Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2270054
[N:1]([CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:9][CH:8]=1)=[O:6])=[N+]=[N-].CO.[ClH:20]>[H][H].[Pd]>[ClH:20].[NH2:1][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:9][CH:8]=1)=[O:6]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 18331085HCID 18331085, Verbindung

Produkt 1

HCID 18613865193813-77-3

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 178418361HCID 178418361, VerbindungLösungsmittel

Versuchsvorschrift

To a solution of 2-azido-4′-ethoxycarbonylactophenone (1.44 g), methanol (41.3 ml) and conc. hydrochloric acid (1.38 ml) was added 10% palladium-activated carbon (73 mg), and stirred for 3 hours in hydrogen atmosphere at 2.8 atm. After 1 hour, the reaction mixture was filtered off, and the filtrate was evaporated under reduced pressure. The solids were slurried in diisopropyl ether, and collected by filtration to give 2-amino-4′-ethoxycarbonylacetophenone hydrochloride (1.40 g).

Aufarbeitung

  1. filtrationthe reaction mixture was filtered off
  2. customthe filtrate was evaporated under reduced pressure
  3. filtrationcollected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-de5b867382fb463397d005c21198c9ac
Quelldatensatz
uspto-grants-2001_12
Patentnummer
US06331521B1

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