Benzoyl chloride → Phenyl-n-[3-(phenylmethoxy)phenyl]carboxamide

HRID 22709

Reaktionsgleichung

Reaktionsgleichung von HRID 22709
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:13]=[CH:14][CH:15]=1)[NH2:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:16](Cl)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(Cl)Cl.O>[C:17]1([C:16]([NH:12][C:11]2[CH:13]=[CH:14][CH:15]=[C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:10]=2)=[O:23])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

5

Edukt 2

HCID 7412Benzoyl chlorideHCID 928923-Benzyloxyaniline

Produkt 1

HCID 13016199Phenyl-n-[3-(phenylmethoxy)phenyl]carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 3-benzyloxyaniline 23 (1.0 g, 5.0 mmol) and TEA (0.74 mL, 5.3 mmol) in CH2Cl2 was added benzoyl chloride (0.61 mL, 5.26 mmol) dropwise and the mixture was allowed to stir overnight. The reaction mixture was diluted with water and the resulting solid was collected by vacuum filtration. The solid was allowed to air dry, to yield compound 25 as a white solid. Synthesis of phenyl{[(3-phenylmethoxy)phenyl]amino}methane-1-thione (26):

Aufarbeitung

  1. filtrationthe resulting solid was collected by vacuum filtration
  2. customto air dry

Quellen und Nachweise

ORD-Eintrag
ord-6692b3a1a0e74eaab5113f25243265bf
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849632B2

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