2-Methyl-1-butanol → N-(phenylacetyl)valine 2-methylbutyl Ester

HRID 2271157

Reaktionsgleichung

Reaktionsgleichung von HRID 2271157
[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:15]([OH:17])=[O:16])[CH:12]([CH3:14])[CH3:13])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][CH:19]([CH2:22][CH3:23])[CH2:20]O>>[CH3:18][CH:19]([CH2:22][CH3:23])[CH2:20][O:16][C:15](=[O:17])[C@H:11]([CH:12]([CH3:13])[CH3:14])[NH:10][C:8](=[O:9])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

3

Edukt 2

HCID 87232-Methyl-1-butanolHCID 853958(2S)-3-methyl-2-(2-phenylacetamido)butanoic acid

Produkt 1

HCID 15481773N-(phenylacetyl)valine 2-methylbutyl Ester

Versuchsvorschrift

Following General Procedure C and using the N-(phenylacetyl)valine prepared in Step A above and 2-methylbutan-1-ol (Aldrich), the title compound was prepared as a diastereomeric mixture. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Aufarbeitung

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Quellen und Nachweise

ORD-Eintrag
ord-6d0f34efbb7b445d984ac3f735fc4751
Quelldatensatz
uspto-grants-2001_12
Patentnummer
US06333351B1

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