1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → HCID 178519813, Verbindung

HRID 2271523Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2271523
C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1.[Br:26][C:27]1[CH:32]=[CH:31][C:30]([NH:33][CH:34]=[C:35]([C:40]([CH:42]2[CH2:44][CH2:43]2)=[O:41])[C:36]([O:38]C)=O)=[CH:29][C:28]=1[F:45]>>[Br:26][C:27]1[CH:32]=[C:31]2[C:30](=[CH:29][C:28]=1[F:45])[N:33]=[CH:34][C:35]([C:40]([CH:42]1[CH2:44][CH2:43]1)=[O:41])=[C:36]2[OH:38]

Komponenten

3

Edukt 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 178500751HCID 178500751, Verbindung

Produkt 1

HCID 178519813HCID 178519813, VerbindungAusbeute 79,2 %

Versuchsvorschrift

To Dowtherm at 250° C. was added methyl 3-(4-bromo-3-fluorophenylamino)-2-(cyclopropanecarbonyl)acrylate (7.5 g, 21.9 mmol) portionwise and the reaction mixture was stirred for 1.5 h. The reaction mixture was cooled to room temperature, diluted with hexanes and the resulting precipitate was filtered to afford the desired product (5.38 g, 79%) as a brown solid: ESI MS m/z 311 [C13H9BrFNO2+H]+.

Aufarbeitung

  1. filtrationthe resulting precipitate was filtered

Quellen und Nachweise

ORD-Eintrag
ord-bed88c9d698b4ce4b419c9ddb8b671bb
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09120749B2

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