Phenol, 4-methoxy-2-nitro- → 2-Amino-4-methoxyphenol

HRID 22723

Reaktionsgleichung

Reaktionsgleichung von HRID 22723
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[C:5]([N+:10]([O-])=O)[CH:4]=1>CO.[Pd]>[NH2:10][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[OH:9]

Komponenten

4

Edukt 1

HCID 15285Phenol, 4-methoxy-2-nitro-

Produkt 1

HCID 14191082-Amino-4-methoxyphenol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Commercially available 4-methoxy-2-nitrophenol (1 g, 5.9 mmol), a compound of formula (C) was dissolved in 10 mL of methanol, and then 10% Pd/C was added to the mixture. The mixture was hydrogenated in a Parr™ shaker at 30 psi until consumption of hydrogen stopped. The mixture was filtered through Celite and concentrated, to yield 2-amino-4-methoxyphenol a compound of formula (d), which was used without further purification.

Aufarbeitung

  1. customThe mixture was hydrogenated in a Parr™ shaker at 30 psi until consumption of hydrogen
  2. filtrationThe mixture was filtered through Celite
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-357d0f6dda4445b290f863c893983868
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849632B2

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