3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole → 3-(4-Piperidinyl)-1H-indole

HRID 227267

Reaktionsgleichung

Reaktionsgleichung von HRID 227267
[NH:1]1[CH2:6][CH:5]=[C:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)[CH2:3][CH2:2]1>CO.[Pd]>[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)[CH2:3][CH2:2]1

Komponenten

4

Edukt 1

HCID 27610233-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole

Produkt 1

HCID 7022353-(4-Piperidinyl)-1H-indole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

19.03 g (0.096 mol) of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole were hydrogenated in a Parr apparatus during 18 h at 3 bar with 2.2 g of Pd/C 10% in 600 ml of methanol. After standard work-up, 16.76 g (87% of yield) of the desired product were obtained.

Quellen und Nachweise

ORD-Eintrag
ord-82f1ca6314c24c078bf152d40688e60d
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560471B2

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