Water → Ethyl 4-(1H-indol-3-yl)piperidine-1-carboxylate

HRID 227268Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 227268
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)[CH2:3][CH2:2]1.Cl[C:17]([O:19][CH2:20][CH3:21])=[O:18].O>ClCCl>[CH2:20]([O:19][C:17]([N:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)[CH2:3][CH2:2]1)=[O:18])[CH3:21]

Komponenten

5

Edukt 3

HCID 962WaterHCID 10928Ethyl chloroformateHCID 7022353-(4-Piperidinyl)-1H-indole

Produkt 1

HCID 11380267Ethyl 4-(1H-indol-3-yl)piperidine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a suspension of 30 g (0.15 mol) of 3-piperidin-4-yl-1H-indole and 28 mL (0.2 mol) in 185 ml of anhydrous dichloromethane, 17 ml (0.18 mol) of ethyl chloroformate were added dropwise keeping the temperature of the reaction below 20° C. After 2 h at room temperature, the crude mixture was poured into 100 ml of water. The organic layer was separated and dried with sodium sulphate. After filtration, the solvent was removed under reduced pressure affording 39 g (95% of yield) of the expected product.

Aufarbeitung

  1. customthe temperature of the reaction below 20° C
  2. customThe organic layer was separated
  3. dry with materialdried with sodium sulphate
  4. filtrationAfter filtration
  5. customthe solvent was removed under reduced pressure
  6. customaffording

Quellen und Nachweise

ORD-Eintrag
ord-8e3468f08205490c909d4ea8817fc8d3
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560471B2

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