Potassium Carbonate → 5-[4-(6-fluoro-1H-indol-3-yl)-piperidin-1-ylmethyl]2-methoxybenzoic acid ethyl ester

HRID 227276

Reaktionsgleichung

[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH3:17][O:18][C:19](=[O:30])[C:20]1[CH:25]=[C:24]([CH2:26]Br)[CH:23]=[CH:22][C:21]=1[O:28][CH3:29].[C:31](=O)([O-])[O-].[K+].[K+]>C(C(CC(C)C)=O)C>[CH2:17]([O:18][C:19](=[O:30])[C:20]1[CH:25]=[C:24]([CH2:26][N:14]2[CH2:15][CH2:16][CH:11]([C:6]3[C:5]4[C:9](=[CH:10][C:2]([F:1])=[CH:3][CH:4]=4)[NH:8][CH:7]=3)[CH2:12][CH2:13]2)[CH:23]=[CH:22][C:21]=1[O:28][CH3:29])[CH3:31]

Komponenten

Reaktionsbedingungen

Temperatur: 90 °C

Versuchsvorschrift

A suspension containing 0.5 g (2.2 mmol) of 6-fluoro-3-piperidin-4-yl-1H-indole, 0.8 g (2.7 mmol) of 5-bromomethyl-2-methoxy-benzoic acid methyl ester and 0.6 g (4.3 mmol) of potassium carbonate in 10 ml of ethyl isobutylketone was heated at 90° C. for 16 hours. The inorganic solid was filtrated and the solvent was removed under reduced pressure. 0.91 g (97% of yield) of the expected product was obtained.

Aufarbeitung

filtrationThe inorganic solid was filtrated
customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag: ord-7d00d126e7a8487a94795ac614c72bf1
Quelldatensatz: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07560471B2

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