Hydrochloric Acid → 3-Cyclopropyl-1,2-oxazole-4-carboxylic acid

HRID 2273573Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2273573
C([O:3][C:4]([C:6]1[C:7]([CH:11]2[CH2:13][CH2:12]2)=[N:8][O:9][CH:10]=1)=[O:5])C.[OH-].[K+].Cl>C(O)C.O.O>[CH:11]1([C:7]2[C:6]([C:4]([OH:5])=[O:3])=[CH:10][O:9][N:8]=2)[CH2:12][CH2:13]1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 57424032HCID 57424032, Verbindung

Produkt 1

HCID 450847723-Cyclopropyl-1,2-oxazole-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

5.6 g (31 mmol) of 3-Cyclopropyl-isoxazole-4-carboxylic acid ethyl ester were slowly added to a solution of 6.1 g (93 mmol, 85% purity) of potassium hydroxide in ethanol/water (1:3, 100 ml) at 0° C. The reaction mixture was stirred at room temperature for 16 h, diluted with water, acidified (pH=2) with 20% aqueous HCl and extracted with dichloromethane. The combined organic layers were dried over sodium sulfate, filtered and the solvent was removed to yield 4.7 g (94%, 95% purity) of the title compound which did not need further purification.

Aufarbeitung

  1. extractionextracted with dichloromethane
  2. dry with materialThe combined organic layers were dried over sodium sulfate
  3. filtrationfiltered
  4. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-53b075df594b4885bcb304873d7abb92
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09125414B2

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