Isopropylamine → N-Isopropyl 4-bromo-2-nitroaniline

HRID 2273598Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2273598
[CH:1]([NH2:4])([CH3:3])[CH3:2].[Br:5][C:6]1[CH:11]=[CH:10][C:9](F)=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=1>C(O)C>[Br:5][C:6]1[CH:11]=[CH:10][C:9]([NH:4][CH:1]([CH3:3])[CH3:2])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=1

Komponenten

4

Edukt 2

HCID 6363IsopropylamineHCID 27363284-Bromo-1-fluoro-2-nitrobenzene

Produkt 1

HCID 2759489N-Isopropyl 4-bromo-2-nitroaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Isopropylamine (3 mL) is added to a solution of 4-bromo-1-fluoro-2-nitrobenzene (700 mg, 3.18 mmol) in ethanol. The reaction may be stirred for an appropriate time at an appropriate temperature, such as room temperature for overnight and concentrated. The residue may be purified by any appropriate method such as Biotage column chromatography to give 4-bromo-N-isopropyl-2-nitroaniline (770 mg).

Aufarbeitung

  1. customThe reaction
  2. concentrationconcentrated
  3. customThe residue may be purified by any appropriate method such as Biotage column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-980a8c9d3e1a4af9b12c51bc77ed8f9e
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09125901B2

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