Triethylamine → Methanesulfonic acid 2-(1-methyl-pyrrolidin-2-yl)-ethyl ester

HRID 227384

Reaktionsgleichung

Reaktionsgleichung von HRID 227384
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][OH:9].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1COCC1>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][O:9][S:18]([CH3:17])(=[O:20])=[O:19]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 933631-Methyl-2-pyrrolidineethanol

Produkt 1

HCID 44627019Methanesulfonic acid 2-(1-methyl-pyrrolidin-2-yl)-ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The 1-methyl-2-pyrrolidineethanol (Aldrich, 0.16 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Quellen und Nachweise

ORD-Eintrag
ord-0dbdb683028e47d7a0c4b45b508af8c3
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560481B2

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