Triethylamine → 2-(Pyridin-3-yl)ethyl methanesulfonate

HRID 227386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 227386
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][OH:9])[CH:2]=1.C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1COCC1>[CH3:17][S:18]([O:9][CH2:8][CH2:7][C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)(=[O:20])=[O:19]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 805153-Pyridineethanol

Produkt 1

HCID 232850562-(Pyridin-3-yl)ethyl methanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The 2-(3-pyridyl)ethan-1-ol (Maybridge, 0.15 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Quellen und Nachweise

ORD-Eintrag
ord-2ac2450a543444788cd7f3abe95e08b2
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560481B2

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