Sulfuryl chloride → Ethyl 2-chloro-3-cyclopropyl-3-oxopropanoate

HRID 2275774Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2275774
S(Cl)([Cl:4])(=O)=O.[CH:6]1([C:9](=[O:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:8][CH2:7]1>ClCCl>[Cl:4][CH:10]([C:9]([CH:6]1[CH2:8][CH2:7]1)=[O:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Komponenten

4

Edukt 2

HCID 24648Sulfuryl chlorideHCID 262979Ethyl 3-cyclopropyl-3-oxopropanoate

Produkt 1

HCID 54244501Ethyl 2-chloro-3-cyclopropyl-3-oxopropanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3.1 ml of sulphuryl chloride (38.2 mmol, 1.05 equivalents) were initially charged in 21 ml of dichloromethane, and 5.68 g of ethyl 3-cyclopropyl-3-oxopropanoate (36.4 mmol) were added dropwise on a water bath. The reaction mixture was stirred at RT for 2 h. The mixture was then washed with water, 5% strength aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution, dried over magnesium sulphate and concentrated. The crude product (6.8 g) was used without further purification for the next reaction.

Aufarbeitung

  1. washThe mixture was then washed with water, 5% strength aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution
  2. dry with materialdried over magnesium sulphate
  3. concentrationconcentrated
  4. customThe crude product (6.8 g) was used without further purification for the next reaction

Quellen und Nachweise

ORD-Eintrag
ord-91476b64f3a6405788f68526136596eb
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09126998B2

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