Water → HCID 3816170, Verbindung

HRID 2275784Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2275784
[NH2:1][CH:2]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[CH2:3][C:4]([OH:6])=[O:5].[C:14]1(=O)[O:19][C:17](=[O:18])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.O>CN(C=O)C>[O:18]=[C:17]1[C:16]2[C:15](=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:14](=[O:19])[N:1]1[CH:2]([C:7]1[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=1)[CH2:3][C:4]([OH:6])=[O:5]

Komponenten

5

Edukt 3

HCID 962WaterHCID 6811Phthalic AnhydrideHCID 5798853-Amino-3-(4-fluorophenyl)propanoic acid

Produkt 1

HCID 3816170HCID 3816170, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
135 °C

Versuchsvorschrift

2.0 g of rac-3-amino-3-(4-fluorophenyl)propanoic acid (10.92 mmol) and 1.62 g of phthalic anhydride (10.92 mmol) were dissolved in 9 ml of DMF and heated at reflux at 135° C. overnight. The reaction solution was added to about 200 ml of water. The solid formed was stirred at RT for about 30 min and then filtered off, washed with water and dried under high vacuum. This gave 3.43 g of the title compound (86% of theory, purity about 86%).

Aufarbeitung

  1. temperatureheated
  2. customThe solid formed
  3. filtrationfiltered off
  4. washwashed with water
  5. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-be1cb000e0fa40c8a04784395db9e57c
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09126998B2

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