Methyl 2-(hydroxymethyl)pyridine-4-carboxylate → Methyl 2-formylisonicotinate
Reaktionsgleichung
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=[CH:5][N:4]=1>C(Cl)Cl.O=[Mn]=O>[CH:2]([C:3]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=[CH:5][N:4]=1)=[O:1]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of methyl 2-(hydroxymethyl)pyridine-4-carboxylate (30 g, 179.64 mmol) in DCM (1 L) was added MnO2 (93.77 g. 1.0778 mol) at r.t. and stirred overnight. The reaction mixture was then filtered and concentrated to afford the title compound (21.3 g, 72%). [M+H] Calc'd for C8H7NO3, 166. Found, 166.
Aufarbeitung
- filtrationThe reaction mixture was then filtered
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-6c865212858146c2b7ba0698c5b715d8
- Quelldatensatz
- uspto-grants-2015_09
- Patentnummer
- US09133166B2
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