3-Chloro-2-fluorobenzaldehyde → 3-Chloro-2-fluorobenzyl alcohol

HRID 2277575Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2277575
[F:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>C1COCC1.C(Cl)Cl>[Cl:10][C:9]1[C:2]([F:1])=[C:3]([CH2:4][OH:5])[CH:6]=[CH:7][CH:8]=1

Komponenten

5

Edukt 2

HCID 7363353-Chloro-2-fluorobenzaldehydeHCID 4311764Sodium borohydride

Produkt 1

HCID 27736063-Chloro-2-fluorobenzyl alcohol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-fluoro-3-chloro-benzaldehyde (4.74 g, 30 mmol) in THF (20 mL) was added NaBH4 (1.48 g, 40 mmol). The resulting mixture was stirred at room temperature for 30 min before diluting with DCM. The organic layer was washed with water and brine. The combined organic layers were dried over anhy. Na2SO4, filtered and concentrated in vacuo to give desired product without further purification (4.8 g, 100%). MS: 161.0 (M+H)+.

Aufarbeitung

  1. washThe organic layer was washed with water and brine
  2. customThe combined organic layers were dried over anhy
  3. filtrationNa2SO4, filtered
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-eee0d38234e948a18495c89494babee2
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133158B2

Notizen zur Reaktion

Wird geladen…