Potassium Carbonate → HCID 68281537, Verbindung

HRID 2278592Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2278592
Br[CH2:2][C:3]([CH3:5])=[CH2:4].C(=O)([O-])[O-].[K+].[K+].[H-].[Na+].[Br:14][C:15]1[C:20]([F:21])=[CH:19][CH:18]=[CH:17][C:16]=1[NH:22][C:23](=[O:25])[CH3:24]>C1(C)C=CC=CC=1.C(OCC)(=O)C.O>[Br:14][C:15]1[C:20]([F:21])=[CH:19][CH:18]=[CH:17][C:16]=1[N:22]([CH2:2][C:3]([CH3:5])=[CH2:4])[C:23](=[O:25])[CH3:24]

Komponenten

8

Edukt 4

HCID 11430Potassium CarbonateHCID 24758Sodium hydrideHCID 3577853-Bromo-2-methyl-1-propeneHCID 68281659HCID 68281659, Verbindung

Produkt 1

HCID 68281537HCID 68281537, VerbindungAusbeute 102,7 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

2 g of 3-bromo-2-methylpropene, 1.9 g of potassium carbonate and 570 mg of sodium hydride (dispersion in oil at 60%) are added to a solution of 3 g of N-(2-bromo-3-fluorophenyl)acetamide in 25 ml of toluene. The reaction mixture is placed under an argon atmosphere and heated at 75° C. for 16 hours. The reaction mixture is treated with a mixture of water and ethyl acetate, and the organic phase is then washed with water and a saturated sodium chloride solution, dried over magnesium sulfate, filtered, and concentrated under reduced pressure, so as to give 3.8 g of N-(2-bromo-3-fluorophenyl)-N-(2-methylallyl)acetamide.

Aufarbeitung

  1. washthe organic phase is then washed with water
  2. dry with materiala saturated sodium chloride solution, dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6659366b4f4c4fb096465c7cad24912a
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133168B2

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