Ethyl Acetate → (2-Methylpyrimidin-5-yl)methanamine

HRID 2278729Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2278729
[N:1]([CH2:4][C:5]1[CH:6]=[N:7][C:8]([CH3:11])=[N:9][CH:10]=1)=[N+]=[N-].C(OCC)(=O)C>[Pd]>[CH3:11][C:8]1[N:9]=[CH:10][C:5]([CH2:4][NH2:1])=[CH:6][N:7]=1

Komponenten

4

Edukt 2

HCID 8857Ethyl AcetateHCID 545950225-(Azidomethyl)-2-methylpyrimidine

Produkt 1

HCID 21294601(2-Methylpyrimidin-5-yl)methanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

A mixture of 5-(azidomethyl)-2-methylpyrimidine (55 mg, 0.00037 mol) in ethyl acetate (20 mL, 0.2 mol), and 10% Pd—C (70 mg) was stirred under H2 (1 atm) for 2 hr. The catalyst was filtered off and filtrate was concentrated in vacuo to afford a white solid. LC/MS m/e 124.3 (M+H+)

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationfiltrate was concentrated in vacuo
  3. customto afford a white solid

Quellen und Nachweise

ORD-Eintrag
ord-ba85c4aa834c45a2993f12ffeb93fcd4
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133122B2

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