Acetone Cyanohydrin → 2-Ethyl-2,5,5-trimethyl-piperazine-1-carboxylic acid tert-butyl ester
Reaktionsgleichung
[C:1]([O:5][C:6]([N:8]1[CH2:17][C:12]2([CH2:16]CC[CH2:13]2)[NH:11][CH2:10][C:9]1([CH3:19])[CH3:18])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:20]C(N)(CC)CN.CC(C)(O)C#N>>[C:1]([O:5][C:6]([N:8]1[CH2:17][C:12]([CH3:13])([CH3:16])[NH:11][CH2:10][C:9]1([CH2:18][CH3:20])[CH3:19])=[O:7])([CH3:2])([CH3:3])[CH3:4]Komponenten
4
Versuchsvorschrift
2-Ethyl-2,5,5-trimethyl-piperazine-1-carboxylic acid tert-butyl ester was synthesized in analogy to 8,8-dimethyl-6,9-diaza-spiro[4.5]decane-9-carboxylic acid tert-butyl ester starting from 2-methylbutane 1,2-diamine and acetone cyanohydrin.