Sodium Hydroxide → HCID 59580006, Verbindung

HRID 2279651Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2279651
C([O:3][C:4]([C:6]1[S:10][C:9]([C:11]2[N:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[N:8][C:7]=1[C:17]([F:20])([F:19])[F:18])=[O:5])C.[OH-].[Na+]>CO.O>[N:16]1[CH:15]=[CH:14][CH:13]=[N:12][C:11]=1[C:9]1[S:10][C:6]([C:4]([OH:5])=[O:3])=[C:7]([C:17]([F:19])([F:20])[F:18])[N:8]=1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 59579876HCID 59579876, Verbindung

Produkt 1

HCID 59580006HCID 59580006, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A mixture of 2-pyrimidin-2-yl-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester (1.6 g) and sodium hydroxide (1.2 g) in MeOH (10 mL) and water (3 mL) is heated at 50° C. with stirring for 30 min, cooled and evaporated. The residue is acidified with citric acid solution and extracted with EtOAc six times. The combined extracts are washed once with brine, dried over Na2SO4 and concentrated to give the title compound as a solid.

Aufarbeitung

  1. temperaturecooled
  2. customevaporated
  3. extractionextracted with EtOAc six times
  4. washThe combined extracts are washed once with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-02dfca3419d748ae88c90c15391661e5
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09133204B2

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