Hydrochloric Acid → (2R)-2-acetamido-3-methoxypropanoic acid
Reaktionsgleichung
[C:1]([NH:4][CH:5]([C:9]([OH:11])=[O:10])[CH2:6][O:7][CH3:8])(=[O:3])[CH3:2].[OH-].[Na+].Cl>O>[C:1]([NH:4][C@H:5]([CH2:6][O:7][CH3:8])[C:9]([OH:11])=[O:10])(=[O:3])[CH3:2]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 25 °C
Versuchsvorschrift
In a vessel, equipped with a magnetic stirrer and pH controller, N-acetyl-O-methyl-D,L-serine (3 g) was dissolved in demineralized water (30 mL) and the pH was adjusted to 7.5-8.0 with 5N sodium hydroxide solution. Acylase I from Porcine Kidney (EC: 3.5.1.14) (50 mg) was added and the solution maintained at 25° C. under mild agitation overnight. The pH was adjusted to 2.7 with concentrated HCl and the aqueous solution injected onto Dowex™ 50WX4-50 ion exchange resin (50 mL) conditioned at pH 3.8. The resulting material was eluted with water at pH 2.4. The aqueous solution thereby obtained was then evaporated to dryness under vacuum to afford the title compound (1.5 g, 50%) as an off-white solid.
Aufarbeitung
- customIn a vessel, equipped with a magnetic stirrer
- additionAcylase I from Porcine Kidney (EC: 3.5.1.14) (50 mg) was added
- washThe resulting material was eluted with water at pH 2.4
- customThe aqueous solution thereby obtained
- customwas then evaporated to dryness under vacuum
Quellen und Nachweise
- ORD-Eintrag
- ord-d3a07d20d77c47be9b81a14f76a28436
- Quelldatensatz
- uspto-grants-2015_09
- Patentnummer
- US09139513B2
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