Bromine → Methyl 4-(5-bromo-6-methoxyquinolin-2-yl)benzoate

HRID 2280476Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2280476
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]1[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=1)[CH:7]=[CH:6]2.[Br:23]Br>C(Cl)Cl>[Br:23][C:4]1[C:3]([O:2][CH3:1])=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8]([C:13]1[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=1)=[N:9]2

Komponenten

4

Edukt 2

HCID 24408BromineHCID 66980098Methyl 4-(6-methoxyquinolin-2-yl)benzoate

Produkt 1

HCID 66980100Methyl 4-(5-bromo-6-methoxyquinolin-2-yl)benzoateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of methyl 4-(6-methoxyquinolin-2-yl)benzoate (630 mg, 2.15 mmol) in DCM (9 mL) was added Br2 (0.3 mL, 6.45 mmol). The reaction mixture was stirred at room temperature overnight. Then the mixture was partitioned with brine and DCM. The precipitate was filtered and dried to give the product as a solid (800 mg, 100%). MS (ESI): m/z=373.0 [M+1]+.

Aufarbeitung

  1. customThen the mixture was partitioned with brine and DCM
  2. filtrationThe precipitate was filtered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0e7a364061254ae785bac70b892c09a7
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09139528B2

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