Benzyl carbamate → HCID 25260225, Verbindung

HRID 2280698

Reaktionsgleichung

Reaktionsgleichung von HRID 2280698
[O:1]1[CH2:6][CH:5]=[CH:4][C:3](=[O:7])[CH2:2]1.[C:8](=[O:18])([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[NH2:9].O.O.O.O.O.[N+]([O-])([O-])=O.[Bi+3].[N+]([O-])([O-])=O.[N+]([O-])([O-])=O>C(Cl)Cl>[O:7]=[C:3]1[CH2:2][O:1][CH2:6][CH:5]([NH:9][C:8](=[O:18])[O:10][CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:4]1

Komponenten

5

Edukt 3

HCID 12136Benzyl carbamateHCID 160911Bismuth nitrate pentahydrateHCID 46725963,6-dihydro-2H-pyran-3-one

Produkt 1

HCID 25260225HCID 25260225, VerbindungAusbeute 73,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

2H-pyran-3(6H)-one (2.33 g, 23.75 mmol), benzyl carbamate (4.31 g, 28.5 mmol), and DCM (2.375 mL) were added to a small vial and stirred vigorously. To the thick syrup was added bismuth(III) nitrate pentahydrate (1.728 g, 3.56 mmol). The vial was capped and the reaction was stirred vigorously overnight. The reaction was diluted with DCM and filtered through a pad of celite. The filtrate was condensed and purified on a 100G SNAP Biotage column (10-100% ethyl acetate in hexane) to give benzyl 5-oxotetrahydro-2H-pyran-3-ylcarbamate (4.35 g, 17.45 mmol, 73.5% yield) as a pale yellow oil; 1H NMR (400 MHz, CDCl3) δ ppm 7.28-7.41 (m, 5H), 5.20-5.28 (m, 1H), 5.05-5.15 (m, 2H), 4.24-4.35 (m, 1H), 4.01-4.06 (m, 1H), 3.89-3.95 (m, 1H), 3.80-3.87 (m, 1H), 2.73 (d, J=5.47 Hz, 1H), 2.64-2.71 (m, 1H).

Aufarbeitung

  1. customThe vial was capped
  2. stirringthe reaction was stirred vigorously overnight
  3. filtrationfiltered through a pad of celite
  4. customcondensed
  5. custompurified on a 100G SNAP Biotage column (10-100% ethyl acetate in hexane)

Quellen und Nachweise

ORD-Eintrag
ord-45bac57ddec846539113dd5d9e70d1d7
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09139534B2

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