Hydrogen Bromide → 3-Amino-2-hydroxy-4-(2-thienyl)butanamide
Reaktionsgleichung
Br.[NH2:2][C:3](=[O:24])[CH:4]([OH:23])[CH:5]([NH:12]C(=O)OCC1C=CC=CC=1)[CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1>C(O)(=O)C>[NH2:12][CH:5]([CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)[CH:4]([OH:23])[C:3]([NH2:2])=[O:24]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
70 ml of 30% HBr in glacial acetic acid were added to 11 g of phenylmethyl [3-amino-2-hydroxy-3-oxo-1-(2-thienylmethyl)propyl]carbamate (29.66 mmol) in 30 ml of glacial acetic acid. After about 2 hours, the mixture was concentrated and the resulting residue was stirred firstly with cyclohexane and then with dichloromethane. 7.8 g of the title compound were obtained as hydrobromide.
Aufarbeitung
- concentrationthe mixture was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-64aa23a38f6243bf8f94dbf84e3cc1ed
- Quelldatensatz
- uspto-grants-2015_09
- Patentnummer
- US09139557B2
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