Hydrochloric Acid → HCID 67464347, Verbindung

HRID 2281176Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2281176
[C:1]1([C:7]2[O:8][CH:9]=[C:10]3[C:18]4[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=4[N:12](S(C4C=CC=CC=4)(=O)=O)[C:11]=23)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].Cl>CS(C)=O.O>[C:1]1([C:7]2[O:8][CH:9]=[C:10]3[C:18]4[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=4[NH:12][C:11]=23)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 104070034H-Furo[3,4-b]indole, 3-phenyl-4-(phenylsulfonyl)-

Produkt 1

HCID 67464347HCID 67464347, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

45 g (123 mmol) of 3-phenyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole and 48 g (856 mmol) of potassium hydroxide in 65 ml of DMSO and 21 ml of water are heated under reflux for 1 h. The mixture is subsequently cooled to room temperature, neutralised using 1M HCl solution and extracted with dichloromethane. The solvent is evaporated in vacuo, and the residue is purified by chromatography (heptane/ethyl acetate 10:1). Yield: 22.4 g (96 mmol), 80%.

Aufarbeitung

  1. temperatureunder reflux for 1 h
  2. extractionextracted with dichloromethane
  3. customThe solvent is evaporated in vacuo
  4. customthe residue is purified by chromatography (heptane/ethyl acetate 10:1)

Quellen und Nachweise

ORD-Eintrag
ord-a0631ac15b5a422ba9876dcaa1b17a25
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09139582B2

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